Antiangiogenic drugs and advanced proliferative diabetic retinopathy Drogas antiangiogênicas em retinopatia diabética proliferativa avançada
نویسندگان
چکیده
Advanced diabetic retinopathy with vitreous hemorrhage or tractional retinal detachment (TDR) is an important cause of severe visual loss in patients with proliferative diabetic retinopathy (PDR), frequently representing an indication for pars plana vitrectomy in diabetic patients. In these cases, surgery is not free from complications such as intraoperative vitreous hemorrhage and retinal rupture. Also, during the postoperative period, these patients may suffer untoward events such as intraocular rebleeding and neovascular glaucoma. Antiangiogenic drugs have been extensively used for the treatment of chorioretinal vascular disorders. The intravitreal use of bevacizumab, ranibizumab and pegaptanib has shown positive effects on diabetic retinopathy. The inhibition of vascular endothelial growth factor (VEGF) by these drugs can induce regression of diabetic neovascular retinopathy and combat exudative phenomena, thus being useful for the preoperative management of these patients. In the present article we review the use of antiangiogenic drugs as adjuvants in pars plana vitrectomy for the treatment of complications of diabetic retinopathy.
منابع مشابه
Intravenous sodium fluorescein enhances the visibility of vitreous during vitrectomy surgery for diabetic retinopathy Fluoresceína sódica intravenosa aumenta a visibilidade do vítreo durante a cirurgia de vitrectomia para retinopatia diabética
1 Doutor, responsável pelo Centro de Pesquisa Rubens Siqueira CPRS – São José do Rio Preto (SP), Brasil; Responsável pelo Departamento de Oftalmologia da Faculdade de Medicina de Catanduva – FAMECA – Catanduva (SP), Brasil; Colaborador em pesquisa do departamento de Retina da USP Ribeirão Preto-SP 2 Doutor, responsável pelo Departamento de Retina da Faculdade de Medicina de Ribeirão Preto da Un...
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